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2145-27-9

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2145-27-9 Structure
IdentificationBack Directory
[Name]

7-Fluoro-4-hydroxy-2H-chromen-2-one
[CAS]

2145-27-9
[Synonyms]

7-Fluoro-4-hydroxycoumarin
7-Fluoro-4-hydroxy-2H-chromen-2-one
7-Fluoro-4-hydroxy-2H-1-benzopyran-2-one
7-Fluoro-4-hydroxy-1(2H)-benzopyran-2-one
2H-1-Benzopyran-2-one, 7-fluoro-4-hydroxy-
[Molecular Formula]

C9H5FO3
[MDL Number]

MFCD11845381
[MOL File]

2145-27-9.mol
[Molecular Weight]

180.13
Chemical PropertiesBack Directory
[Melting point ]

220-225°C
[Boiling point ]

339.4±42.0 °C(Predicted)
[density ]

1.549±0.06 g/cm3(Predicted)
[pka]

4.50±1.00(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
[Hazard Codes ]

Xn
[Risk Statements ]

22
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Reactant for:
  • Enantioselective synthesis of polycyclic coumarins via in situ formed primary amine-imine-catalyzed asymmetric Michael addition to cyclic enones
  • Preparation of dicoumarol analogs as inhibitors of human NAD(P)H quinone oxidoreductase-1 (NQO1) as agents active against human pancreatic and colon cancer cells
  • Imidazolidinecarboxylic acid-catalyzed asymmetric Michael reaction with unsaturated ketones in a highly atom-economic catalytic one-step formation of optically active warfarin anticoagulant
  • Asymmetric synthesis of functionalized α-keto esters and their hemiketal and hemiaminal derivatives via direct Michael addition with unsaturated α-keto esters catalyzed by bisoxazoline-copper(II) complexes
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