ChemicalBook >> CAS DataBase List >>4'-Methoxyacetophenone
4'-Methoxyacetophenone
- CAS No.
- 100-06-1
- Chemical Name:
- 4'-Methoxyacetophenone
- Synonyms
- 4-METHOXYACETOPHENONE;ACETANISOLE;1-(4-METHOXYPHENYL)ETHANONE;4-ACETYLANISOLE;P-ACETYLANISOLE;Acetanisol;P-METHOXYACETOPHENONE;Ethanone, 1-(4-methoxyphenyl)-;Vananote;p-Acetoanisole
- CBNumber:
- CB1132155
- Molecular Formula:
- C9H10O2
- Molecular Weight:
- 150.17
- MDL Number:
- MFCD00008745
- MOL File:
- 100-06-1.mol
- MSDS File:
- SDS
Last updated:2024-09-25 16:17:47
Melting point | 36-38 °C (lit.) |
---|---|
Boiling point | 152-154 °C/26 mmHg (lit.) |
Density | 1.08 |
vapor pressure | 0.42Pa at 20℃ |
refractive index | 1.5470 (estimate) |
FEMA | |
Flash point | >230 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | H2O: soluble2.474g/L at 20°C |
form | Crystals or Crystalline Powder |
color | White |
Odor | at 100.00 %. sweet hawthorn anisic powdery balsamic acacia |
Odor Type | anisic |
Water Solubility | insoluble |
Sensitive | Light Sensitive |
JECFA Number | 810 |
BRN | 742313 |
InChIKey | NTPLXRHDUXRPNE-UHFFFAOYSA-N |
LogP | 1.79 at 20℃ |
CAS DataBase Reference | 100-06-1(CAS DataBase Reference) |
Substances Added to Food (formerly EAFUS) | |
FDA UNII | |
NIST Chemistry Reference | |
EPA Substance Registry System |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22-38-36/38-20/21/22 | |||||||||
Safety Statements | 37-37/39-26-36 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | AM9240000 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29145000 | |||||||||
Toxicity | The acute oral LD50 value in rats was reported as 1.72 g/kg (1.47-1.97 g/kg) (Moreno, 1973). The acute dermal LD50 value in rabbits was reported as > 5 g/kg (Moreno, 1973). | |||||||||
NFPA 704 |
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4'-Methoxyacetophenone price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | W200506 | Acetanisole ≥98%, FCC, FG | 100-06-1 | 1kg | $141 | 2025-03-01 | Buy |
Sigma-Aldrich | W200506 | Acetanisole ≥98%, FCC, FG | 100-06-1 | 5kg | $461 | 2025-03-01 | Buy |
Sigma-Aldrich | 117374 | 4′-Methoxyacetophenone 99% | 100-06-1 | 5g | $36.4 | 2025-03-01 | Buy |
Sigma-Aldrich | 117374 | 4′-Methoxyacetophenone 99% | 100-06-1 | 1kg | $131 | 2025-03-01 | Buy |
Sigma-Aldrich | W200506 | Acetanisole ≥98%, FCC, FG | 100-06-1 | 25kg | $1650 | 2024-06-20 | Buy |
4'-Methoxyacetophenone Chemical Properties,Uses,Production
Identification
▼
▲
CAS.No.:
100-06-1
FL.No.:
7.038
FEMA.No.:
2005
NAS.No.:
2005
CoE.No.:
570
EINECS.No.:
202-815-9
JECFA.No.:
810
Description
Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors.Regulatory Status
CoE: Approved. Bev.: 10 ppm; Food: 20 ppm
FDA: 21 CFR 172.515
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2001).
Usage
Reported uses (ppm): (FEMA, 1994)
▼
▲
Food Category
Usual
Max.
Alcoholic.beverages
0.0001
0.0001
Baked.goods
1.5
2
Chewing.gum
110
110
Frozen.dairy
1
2
Gelatins,.puddings
0.2
0.2
Hard.candy
278.3
335
Meat.products
100
100
Nonalcoholic.beverages
7.8
150
Soft.candy
2.1
31
Natural occurrence
Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).Chemical Properties
WHITE CRYSTALS OR CRYSTALLINE POWDERChemical Properties
Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavorsChemical Properties
4-Methoxyacetophenone occurs in anise oil. It forms white crystals (mp 38°C) with a sweet odor, reminiscent of hawthorn. 4-Methoxyacetophenone is prepared by Friedel–Crafts acetylation of anisole. A modern process uses ??-zeolites as Friedel–Crafts catalysts in combination with a continuous flow technology. 4-Methoxyacetophenone is used in soap perfumesOccurrence
Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).Uses
4'-Methoxyacetophenone is a solid, pale yellow flavoring agent with a hawthornlike odor. It is soluble in most fixed oils and propylene glycol, and it is insoluble in glycerin and mineral oil. It is obtained by chemical synthesis. This flavoring substance or its adjuvant may be safely used in food in the minimum quantity required to produce its intended flavor. It can be used alone or in combination with other flavoring substances or adjuvants. It is also termed p-methoxyacetophenone.Uses
4'-Methoxyacetophenone is used as a component of perfumes and as chemical intermediate in the manufacture of pharmaceuticals, resins, flavouring agents. And also used to study ruthenium catalyzed step growth copolymerization of 4?-methoxyacetophenone with α,ω-dienes to yield copolymers.Uses
Perfumery (for floral odors), flavoring.Preparation
From anisole and acetyl chloride in the presence of aluminum chloride and carbon disulfide; from anisole and acetic acid in the presence of boron trifluoride.Definition
ChEBI: A member of the class of acetophenones that is acetophenone substituted by a methoxy group at position 4.Taste threshold values
Taste characteristics at 10 ppm: sweet, anisic, fruity, cherry with powdery vanilla nuances.Synthesis Reference(s)
The Journal of Organic Chemistry, 46, p. 5414, 1981 DOI:
Synthetic Communications, 26, p. 291, 1996 DOI:
Tetrahedron Letters, 35, p. 9471, 1994 DOI:
General Description
4′-Methoxyacetophenone undergoes biocatalytic enantioselective reduction using immobilized Rhodotorula sp. AS2.2241 cells to yield (S)-1-(4-methoxyphenyl) ethanol in a hydrophilic ionic liquid-containing co-solvent system.
Flammability and Explosibility
Not classifiedSafety Profile
Moderately toxic by ingestion. Human systemic effects by inhalation: pulse rate increase without fall in blood pressure and blood pressure elevation. A skin irritant. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.Purification Methods
Crystallise the ketone from diethyl ether/pet ether. [Beilstein 8 IV 340.]4'-Methoxyacetophenone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
4-(1,2,3-THIADIAZOL-4-YL)PHENOL
3-(4-Methoxyphenyl)-1H-pyrazole-5-carboxamide ,97%
5-AMINO-3-(4-METHOXYPHENYL)ISOXAZOLE
3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOHYDRAZIDE
4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOLE
2-Bromo-4'-methoxyacetophenone
5-(4-METHOXY-PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
5-(4-METHOXY-PHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE
4-Nitroanisole
2-(4-bromophenyl)-1,3,4-oxadiazole
1of4
Global( 668)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12452 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
View Lastest Price from 4'-Methoxyacetophenone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2025-04-12 | 4'-Methoxyacetophenone
100-06-1
|
US $5.00 / KG | 1KG | ≥99% | 200mt/year | Jinan Finer Chemical Co., Ltd | ||
2025-01-15 | 4'-Methoxyacetophenone
100-06-1
|
US $0.00 / kg | 1kg | 99.9% | 20tons | Shanghai Hengmao New Materials Technology CO., LIMITED | ||
2024-09-12 | 4'-Methoxyacetophenone
100-06-1
|
US $30.00 / kg | 1kg | 99% | 20 tons | Anhui Ruihan Technology Co., Ltd |
- 4'-Methoxyacetophenone
100-06-1
- US $5.00 / KG
- ≥99%
- Jinan Finer Chemical Co., Ltd
- 4'-Methoxyacetophenone
100-06-1
- US $0.00 / kg
- 99.9%
- Shanghai Hengmao New Materials Technology CO., LIMITED
- 4'-Methoxyacetophenone
100-06-1
- US $30.00 / kg
- 99%
- Anhui Ruihan Technology Co., Ltd
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