ChemicalBook >> CAS DataBase List >>Econazole nitrate
Econazole nitrate
- CAS No.
- 24169-02-6
- Chemical Name:
- Econazole nitrate
- Synonyms
- Pargin;Amicel;Micogin;Gynoryl;SQ 13050;Micofugal;e Nitrate;NSC 243115;Gyno-Pevaril;Gyno-prevaryl
- CBNumber:
- CB3173103
- Molecular Formula:
- C18H16Cl3N3O4
- Molecular Weight:
- 444.7
- MDL Number:
- MFCD00058160
- MOL File:
- 24169-02-6.mol
Last updated:2024-08-21 13:09:42
Melting point | 162°C |
---|---|
storage temp. | Inert atmosphere,Room Temperature |
solubility | chloroform/methanol: soluble25mg/mL (choloroform:methanol (1:1)) |
form | powder |
color | white to off-white |
Water Solubility | <0.1 g/100 mL at 19 ºC |
Merck | 14,3502 |
InChIKey | DDXORDQKGIZAME-UHFFFAOYSA-N |
CAS DataBase Reference | 24169-02-6(CAS DataBase Reference) |
EWG's Food Scores | |
FDA UNII | |
EPA Substance Registry System |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319 | |||||||||
Precautionary statements | P264-P270-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 22-36/38-36/37/38 | |||||||||
Safety Statements | 26-36-36/37 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | NI4450000 | |||||||||
HS Code | 29332900 | |||||||||
Toxicity | LD50 in mice, rats (mg/kg): 462.7, 667.7 orally (Thienpont) | |||||||||
NFPA 704 |
|
Econazole nitrate price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | E4632 | Econazole nitrate salt | 24169-02-6 | 5g | $75.6 | 2025-03-01 | Buy |
Sigma-Aldrich | E4632 | Econazole nitrate salt | 24169-02-6 | 25g | $326 | 2025-03-01 | Buy |
TCI Chemical | E0957 | Econazole Nitrate >98.0%(HPLC)(T) | 24169-02-6 | 5g | $56 | 2025-03-01 | Buy |
TCI Chemical | E0957 | Econazole Nitrate >98.0%(HPLC)(T) | 24169-02-6 | 25g | $197 | 2025-03-01 | Buy |
Alfa Aesar | J63173 | Econazole nitrate | 24169-02-6 | 5g | $68 | 2025-03-01 | Buy |
Econazole nitrate Chemical Properties,Uses,Production
Description
Econazole nitrate is the nitrate salt form of Econazole. It belongs to imidazole-class antifungal medication sold in various places around the world including US, Canada, Western Europe, and Asia. It is usually manufactured into cream form for sale. Econazole nitrate is mainly used for the treatment of skin infections including athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch caused by fungi such as Trichophyton rubrum, Trichophyton tonsurans and Microsporum audouini. As an imidazole-class drug, Econazole nitrate takes effects through inhibiting the biosynthesis of ergosterol, a key component of fungal cell membrane, thus disrupting the normal permeability of fungal membrane. This causes leakage of essential cellular contents of fungi, further killing them.References
//www.rxlist.com/econazole-nitrate-cream-drug/clinical-pharmacology.htm
//en.wikipedia.org/wiki/Econazole
//www.pdr.net/drug-summary/Econazole-Nitrate-econazole-nitrate-731
Chemical Properties
White to Off-White SolidOriginator
Pevaryl,Cilag Chemie,France,1976Uses
Azole antifungalUses
Antifungal;Ergosterol synthesis inhibitionUses
Econazole nitrate is an antifungal agent of the imidazole type used in topical and vaginal preparations to prevent growth of dermatophytes, yeast, and mold.Manufacturing Process
A suspension of 10.3 parts of α-(2,4-dichlorophenyl)-imidazole-1-ethanol and 2.1 parts of sodium hydride in 50 parts of dry tetrahydrofuran is stirred andrefluxed for 2 hours. After this reaction-time, the evolution of hydrogen is ceased. Then there are added successively 60 parts dimethylformamide and 8 parts of p-chlorobenzylchloride and stirring and refluxing is continued for another two hours. The tetrahydrofuran is removed at atmospheric pressure. The dimethylformamide solution is poured onto water. The product, 1-[2,4- dichloro-β-(p-chlorobenzyloxy)phenethyl]imidazole, is extracted with benzene. The extract is washed with water, dried, filtered and evaporated in vacuo. From the residual oily free base, the nitrate salt is prepared in the usual manner in 2-propanol by treatment with concentrated nitric acid, yielding, after recrystallization of the crude solid salt from a mixture of 2-propanol, methanol and diisopropylether, 1-[2,4-dichloro-β-(pchlorobenzyloxy)phenethyl]imidazole nitrate; MP 162°C.brand name
Spectazole (Johnson & Johnson).Therapeutic Function
AntifungalGeneral Description
White crystalline powder.Air & Water Reactions
Insoluble in water.Fire Hazard
Flash point data for Econazole nitrate are not available; however, Econazole nitrate is probably combustible.Biochem/physiol Actions
Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.Econazole nitrate Preparation Products And Raw materials
Global( 311)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Changzhou Rokechem Technology Co., Ltd. | 18758118018 | sales001@rokechem.com | China | 255 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2504 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21698 | 55 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3911 | 58 |
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | +8615377521700 | wangwendy93@gmail.com | China | 868 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 | CHINA | 2783 | 58 |
View Lastest Price from Econazole nitrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2025-03-16 | Econazole nitrate
24169-02-6
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | ||
2024-08-21 | Econazole nitrate
24169-02-6
|
US $10.00 / kg | 1kg | 99% | 1000tons | Henan Bao Enluo International TradeCo.,LTD | ||
2024-07-29 | Econazole Nitrate
24169-02-6
|
US $0.00-0.00 / Kg | 1Kg | 99%;USP/EP/CP | 1-10000kgs | Changzhou Rokechem Technology Co., Ltd. |
- Econazole nitrate
24169-02-6
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
- Econazole nitrate
24169-02-6
- US $10.00 / kg
- 99%
- Henan Bao Enluo International TradeCo.,LTD
- Econazole Nitrate
24169-02-6
- US $0.00-0.00 / Kg
- 99%;USP/EP/CP
- Changzhou Rokechem Technology Co., Ltd.
24169-02-6(Econazole nitrate)Related Search:
1of4
(RS)-1-[2,4-DICHLORO-BETA-(P-CHLOROBENZYLOXY)PHENETHYL]-IMIDAZOLE NITRATE
1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazolium nitrate
ECONAZOLE NITRATE 99%-101%
ECONAZOLE NITRATE
ECONAZOLE NITRATE SALT
ECONAZOL NITRATE
1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole nitrate
1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]-1h-imidazole mononitrate
1-[2-([4-CHLOROPHENYL]METHOXY)-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE NITRATE
1-[2-([4-CHLOROPHENYL]METHOXY)-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE NITRATE SALT
1H-Imidazole, 1-2-(4-chlorophenyl)methoxy-2-(2,4-dichlorophenyl)ethyl-, mononitrate
1-[2-(4-Chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
Gyno-Pevaril
Imidazole, 1-[2,4-dichloro-β-[(p-chlorobenzyl)oxy]phenethyl]-, mononitrate (8CI)
Micofugal
Micogin
NSC 243115
Pargin
SQ 13050
1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, nitrate
Gyno-prevaryl
Amicel
1-[2-(4-chlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole
1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
1H-Imidazole, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-, nitrate (1:1)
Econazole nitrate salt,1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole
ECONAZOLENITRATE1%
Econazole 
Econazole nitrate (Spectazole)
Gynoryl
1-(2-((4-chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-iMidazole nitrate
1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, nitrate (1:1)
econazole nitrate:1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)-ethyl)-1h-IMIDAZOLE mononitrate
1-(2-((2-chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate
Econazole nitrate USP/EP/BP
Econazole nitrate (NSC 243115
Bifonazole Solution, 100ppm
Econazole nitrate, 98.5%
EconazoleNitrate>
e Nitrate
24169-02-6 Econazole Nitrate
Miconazole EP Impurity B as Nitrate
Miconazole Nitrate EP Impurity B as Nitrate
24169-02-6
24169-02-6;68797-31-9
C18H16Cl3N3O4
C18H14Cl3N2OHNO3
Aromatics
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals
Spectazole
Pyridines
Aromatic Nitriles
Organics
ACTIVE PHARMACEUTICAL INGREDIENTS
24169-02-6