ChemicalBook >> CAS DataBase List >>Oxatomide
Oxatomide
- CAS No.
- 60607-34-3
- Chemical Name:
- Oxatomide
- Synonyms
- Tinse;Truxa;tinset;r35443;Dasten;Cobiona;Celtect;kw-4354;Cenacert;Fensedyl
- CBNumber:
- CB3210840
- Molecular Formula:
- C27H30N4O
- Molecular Weight:
- 426.55
- MDL Number:
- MFCD00211147
- MOL File:
- 60607-34-3.mol
- MSDS File:
- SDS
Last updated:2025-03-19 15:37:51
Melting point | 153.60C |
---|---|
Boiling point | 541.98°C (rough estimate) |
Density | 1.1239 (rough estimate) |
refractive index | 1.6000 (estimate) |
storage temp. | Refrigerator |
solubility | DMSO: soluble |
form | White solid. |
pka | 12.20±0.30(Predicted) |
color | white |
CAS DataBase Reference | 60607-34-3(CAS DataBase Reference) |
FDA UNII | |
ATC code |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P280-P305+P351+P338 |
Hazard Codes | Xn,Xi |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |
RTECS | DE2276000 |
Toxicity | LD50 in guinea pigs, mice, rats (mg/kg): 320, >2560, >2560 orally; 23, 27, 30 i.v. (Richards) |
Oxatomide price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | O9387 | Oxatomide ≥99% | 60607-34-3 | 10mg | $324 | 2025-03-01 | Buy |
TRC | O845100 | Oxatomide | 60607-34-3 | 50mg | $495 | 2022-12-16 | Buy |
Usbiological | O8107 | Oxatomide | 60607-34-3 | 10mg | $403 | 2022-12-16 | Buy |
ChemScene | CS-0081837 | Oxatomide 99.47% | 60607-34-3 | 50mg | $600 | 2022-12-16 | Buy |
Medical Isotopes, Inc. | 12818 | Oxatomide | 60607-34-3 | 10mg | $860 | 2022-12-16 | Buy |
Oxatomide Chemical Properties,Uses,Production
Chemical Properties
White PowderOriginator
Tinset,Janssen,W. Germany ,1981Uses
Orally active anti-allergic agent; related structurally to cinnarizine and having a novel biphasic mode of action.Uses
Inhibits the release and actions of leukotrienesDefinition
ChEBI: Oxatomide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug. It has a role as a geroprotector, a H1-receptor antagonist, an anti-allergic agent, an anti-inflammatory agent and a serotonergic antagonist. It is a N-alkylpiperazine, a member of benzimidazoles and a diarylmethane.Manufacturing Process
A mixture of 53 parts of 1-(3chloropropyl)-2H-benzimidazol-2one, 5 parts of 1-(diphenylmethyl)piperazine, 6.4 parts of sodium bicarbonate and 200 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with waterseparator. After cooling, water is added and the layers are separated. The 4methyl-2pentanone phase is dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and 5% of methanol as eluent. The pure fractions are collected and the eluent is evaporated. The oily residue is crystallized from a mixture of 2,2'-oxybispropane and a small amount of 2-propanol. The product is filtered off and dried, yielding 1-[3-[4-(diphenylmethyl)-1piperazinyl]propyl]-2H-benzimidazole-2-one; melting point 153.6°C.Therapeutic Function
AntiallergicSafety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Used to treat allergies and asthma. When heated to decomposition it emits toxic fumes of NOx.Synthesis
Oxatomide is synthesized by alkylation of 1-diphenylmethylpiperazine with 1-(3-chloropropyl)-1,3-dihydro-2Hbenzimidazol- 2-one in the presence of Na2CO3 . In addition to its histamine H1 receptor antagonistic effect, oxatomide may have mast-cell stabilizing activities .Oxatomide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 120)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3959 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9802 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29831 | 58 |
Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
View Lastest Price from Oxatomide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-07-20 | Oxatomide
60607-34-3
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | ||
2022-06-17 | Oxatomide USP/EP/BP
60607-34-3
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
- Oxatomide
60607-34-3
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
- Oxatomide USP/EP/BP
60607-34-3
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
60607-34-3(Oxatomide)Related Search:
1of4
OXATOMIDE
oxatomida
r35443
tinset
1-[3-[4-(DIPHENYLMETHYL)-1-PIPERAZINYL]PROPYL]-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE
Celtect
Cobiona
Dasten
Tinse
1-[3-[4-(Diphmylmethyl)-1-piperazirlyI]propyl]-1,3-dihydro-2H-benzimidazol-2one
Cenacert
Fensedyl
KW-4354:McN-JR-35443
Truxa
1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2h-benzimidazol-2
1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-2-benzimidazolinone
1,3-dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-2h-benzimidazol-2-on
2h-benzimidazol-2-one,1,3-dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propy
kw-4354
oxatimide
3-[3-[4-(Diphenylmethyl)piperazino]propyl]-1H-benzoimidazole-2(3H)-one
OxatoMide API
1-(3-(4-Benzhydrylpiperazin-1-yl)propyl)-1H-benzo[d]iMidazol-2(3H)-one
3-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-1H-benzimidazol-2-one
2H-Benzimidazol-2-one, 1-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-
Oxatomide USP/EP/BP
OxatomideQ: What is
Oxatomide Q: What is the CAS Number of
Oxatomide Q: What is the storage condition of
Oxatomide Q: What are the applications of
Oxatomide
Zinc Acexamate Impurity 6
1-(3-(4-Benzhydrylpiperazin-1-yl)propyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
Oxatomide Anyhdrous
60607-34-3
C27H30NO3
C27H30N4O
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Cell Signaling and Neuroscience
Immune Cell Signaling and Blood
Immune System Regulation
Immunomodulators and Antibiotics
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