ChemicalBook >> CAS DataBase List >>Epalrestat
Epalrestat
- CAS No.
- 82159-09-9
- Chemical Name:
- Epalrestat
- Synonyms
- 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo;2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid;e)-(e;Eabeth;Epatat;Kinedak;Epa-API;Ipastat;ONO 2235;Epalrest
- CBNumber:
- CB6312501
- Molecular Formula:
- C15H13NO3S2
- Molecular Weight:
- 319.4
- MDL Number:
- MFCD00865484
- MOL File:
- 82159-09-9.mol
Last updated:2025-03-12 13:29:27
Melting point | 210-217 C |
---|---|
Boiling point | 516.8±60.0 °C(Predicted) |
Density | 1.43±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO: soluble5mg/mL, clear (warmed) |
pka | 3.62±0.10(Predicted) |
form | powder |
color | yellow to orange |
Merck | 14,3605 |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
InChI | InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8- |
InChIKey | CHNUOJQWGUIOLD-NFZZJPOKSA-N |
SMILES | S1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S |
EWG's Food Scores | |
FDA UNII |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H300 | |||||||||
Precautionary statements | P264-P270-P301+P310+P330-P405-P501 | |||||||||
RIDADR | 2811 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | XJ5131855 | |||||||||
HS Code | 2932.99.7000 | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | II | |||||||||
NFPA 704 |
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Epalrestat price More Price(59)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0527 | Epalrestat ≥98% (HPLC) | 82159-09-9 | 10mg | $128 | 2025-03-01 | Buy |
Sigma-Aldrich | SML0527 | Epalrestat ≥98% (HPLC) | 82159-09-9 | 50mg | $496 | 2025-03-01 | Buy |
TCI Chemical | E0906 | Epalrestat >98.0%(HPLC)(T) | 82159-09-9 | 1g | $135 | 2025-03-01 | Buy |
TCI Chemical | E0906 | Epalrestat >98.0%(HPLC)(T) | 82159-09-9 | 5g | $337 | 2025-03-01 | Buy |
Cayman Chemical | 15214 | Epalrestat ≥98% | 82159-09-9 | 5mg | $73 | 2025-03-01 | Buy |
Epalrestat Chemical Properties,Uses,Production
Description
Epalrestat is the second aldose reductase inhibitor to be introduced worldwide and the first to be launched in Japan. The compound is indicated for the treatment of diabetic neuropathy. It is also being investigated for diabetic retinopathy and nephropathy.Chemical Properties
Red SolidOriginator
Ono (Japan)Uses
An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.Uses
Epalrestat has been used as an aldose reductase inhibitor:
- in the dahomey larvae diet fed forDrosophila
- for non-irradiated and X-ray irradiated human aldose reductase
- to test its protective effect in mice with bleomycin-induced pulmonary fibrosis
Uses
Epalrestat is an aldose reductase inhibitor with IC50 of 72 nMDefinition
ChEBI: A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.brand name
KinedakBiochem/physiol Actions
Epalrestat inhibits Aldose Reductase (AR) involved in the rate limiting step in the conversion of glucose to sorbitol under hyperglycemic conditions. Aldose reductase has been the target of multiple clinical investigatons to treat diabetic neuropathy and retinopathy. Epalrestat is an approved drug in Japan and India, used for the treatment of diabetic neuropathy.References
1) Kikkawa?et al. (1983)?Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235), on peripheral nerve disorders in streptozotocin diabetic rats; Diabetologica,?24?290 2) Terashima?et al. (1984)?Effects of a new aldose reductase inhibitor on various tissues in vitro; J. Pharmacol. Exp. Ther.,?229?226 3) Ramirez and Borja (2008)?Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy; Pharmacotherapy,?28?646Epalrestat Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 460)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
Shanghai Jinhuan Chemical CO.,LTD. | +86-21-52210535 +8613162045318 | sales@jinhchem.com | China | 332 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12452 | 58 |
Shanghai Joiny Pharmaceutical Co.,LTD | +8613681955282 | gyd@joiny-pharma.com | China | 228 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
View Lastest Price from Epalrestat manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2025-04-10 | (E,E)-2-[5-(2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
82159-09-9
|
US $0.00 / kg | 1kg | 98% | 1000kg | Shanghai Joiny Pharmaceutical Co.,LTD | ||
2025-03-08 | Epalrestat
82159-09-9
|
US $10.00 / kg | 1kg | 99% | 1000kg | Nantong Guangyuan Chemicl Co,Ltd | ||
2024-11-14 | Antidiabetic API
82159-09-9
|
US $0.00-0.00 / kg | 1kg | 99% | 50000kg | Hebei Yibangte Import and Export Co. , Ltd. |
- (E,E)-2-[5-(2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
82159-09-9
- US $0.00 / kg
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
- Epalrestat
82159-09-9
- US $10.00 / kg
- 99%
- Nantong Guangyuan Chemicl Co,Ltd
- Antidiabetic API
82159-09-9
- US $0.00-0.00 / kg
- 99%
- Hebei Yibangte Import and Export Co. , Ltd.
82159-09-9(Epalrestat)Related Search:
5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet
e)-(e
EPALRESTAT
(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
AKOS BBS-00007767
OTAVA-BB BB7211260020
Epalrest
Epalrestat, 99.5%
EPALRESTAT(KINEDAK)
5-[(1Z,2E)-2-METHYL-3-PHENYLPROPENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINEACETICACID(EPALRESTAT)
ONO 2235
Epalresta
2-((E)-5-((E)-2-METHYL-3-PHENYLALLYLIDENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)ACETIC ACID
Epatrestat
3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-
5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
[5-[(1Z,2E)-2-Methyl-3-phenylallylidene]-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
Eabeth
Epatat
Quinedac
Kinedak
(E,E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazo-lidineaeetic acid
(5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid
He IpaneMa Division
2-[(5Z)-5[(E)-3-PHENIL-2-METHYLPROP-2-ENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINYL] ACETIC ACID
Epalrestat>
Epalrestat Epalrestat
Epalrestat RS
3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)-
Epalrestat USP/EP/BP
Epalrestat (ONO2235)
EpalrestatQ: What is
Epalrestat Q: What is the CAS Number of
Epalrestat Q: What is the storage condition of
Epalrestat Q: What are the applications of
Epalrestat
Epa-API
Ipastat
According to Mr He
2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid
3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo
Antidiabetic API
Ipasetam
82159-09-9
81259-09-9
C15H13NO3S2
API
Hormone Drugs
Aromatics
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals
Sulfur & Selenium Compounds
API's
Treatment of diabetic neuropathy
82159-09-9