ChemicalBook >> CAS DataBase List >>4-Trifluoromethylphenol
4-Trifluoromethylphenol
- CAS No.
- 402-45-9
- Chemical Name:
- 4-Trifluoromethylphenol
- Synonyms
- 4-(TRIFLUOROMETHYL)PHENOL;TFMPO;P-Trifluoromethyl;TRIFLUORO-PARA-CRESOL;Fluoxetine Impurity 4;4-HYDROXYBENZOTRIFLUORI;4-trifluorotoluolphenol;p-TrifluoroMethylphenyl;α,α,α-Trifluoro-p-cresol;Fluoxetine EP Impurity D
- CBNumber:
- CB6371577
- Molecular Formula:
- C7H5F3O
- Molecular Weight:
- 162.11
- MDL Number:
- MFCD00002363
- MOL File:
- 402-45-9.mol
- MSDS File:
- SDS
Last updated:2024-11-02 15:05:42
Melting point | 45-47 °C(lit.) |
---|---|
Boiling point | 71.5-72 °C (8 mmHg) |
Density | 1.3226 (estimate) |
Flash point | 183 °F |
storage temp. | Store at <= 20°C. |
Water Solubility | Insoluble in water |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
pka | pK1:8.675 (25°C) |
form | Crystals |
color | White to yellow-brown |
BRN | 1637019 |
Stability | Light Sensitive |
InChIKey | BAYGVMXZJBFEMB-UHFFFAOYSA-N |
CAS DataBase Reference | 402-45-9(CAS DataBase Reference) |
FDA UNII | |
NIST Chemistry Reference | |
EPA Substance Registry System |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS02,GHS05,GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H228-H301-H315-H318-H335 | |||||||||
Precautionary statements | P210-P240-P280-P301+P310-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 22-37/38-41-36/37/38 | |||||||||
Safety Statements | 26-39-24/25 | |||||||||
RIDADR | UN 2926 4.1/PG 2 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Irritant/Keep Cold | |||||||||
PackingGroup | Ⅱ | |||||||||
HS Code | 29081000 | |||||||||
NFPA 704 |
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4-Trifluoromethylphenol price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 8.41244 | 4-Hydroxybenzotrifluoride for synthesis | 402-45-9 | 1g | $53.1 | 2025-03-01 | Buy |
Sigma-Aldrich | 178470 | 4-(Trifluoromethyl)phenol 97% | 402-45-9 | 1g | $54.8 | 2025-03-01 | Buy |
Sigma-Aldrich | 8.41244 | 4-Hydroxybenzotrifluoride for synthesis | 402-45-9 | 5G | $215 | 2025-03-01 | Buy |
Sigma-Aldrich | 178470 | 4-(Trifluoromethyl)phenol 97% | 402-45-9 | 5g | $124 | 2025-03-01 | Buy |
TCI Chemical | H0644 | 4-Hydroxybenzotrifluoride >98.0%(GC)(T) | 402-45-9 | 5g | $79 | 2025-03-01 | Buy |
4-Trifluoromethylphenol Chemical Properties,Uses,Production
Preparation method
Chlorosilane and bromotrifluoromethane at-59℃form trifluoromethylsilane. Trifluoromethylsilane and benzoquinone in the presence of catalyst form 4-triethylsiloxy-4-trifluoromethyl-2,5-cyclohexadien-1-ketone which is reduced by zinc powder to p-trifluoromethylphenol with a yield of 71%. This method avoids the use of hydrofluoric acid in the traditional process but should be carried out under anhydrous conditions.If there were water trifluoromethyl silane would rapidly become silanol under the effect of water and alkali. The catalyst used in the reaction is alkali of which the strength has nothing to do with the catalytic activity. By now the role of catalyst is still unknown but the reaction can not proceed without catalyst.Chemical Characteristics
Off-white crystalUses
For intermediate of medicine and pesticide.Chemical Properties
White to yellowish-brown crystalsUses
4-(Trifluoromethyl)phenol (4-hydroxybenzotrifluoride) was used in the synthesis of diaryl ether.Uses
Intermediates of Liquid CrystalsDefinition
ChEBI: 4-(trifluoromethyl)phenol is a member of the class of (trifluoromethyl)benzenes that is p-cresol in which the methyl group is perfluorinated. It is a metabolite of the drug fluoxetine. It has a role as a marine xenobiotic metabolite and a drug metabolite. It is a member of phenols and a member of (trifluoromethyl)benzenes. It is functionally related to a (trifluoromethyl)benzene and a p-cresol.Synthesis Reference(s)
The Journal of Organic Chemistry, 54, p. 2873, 1989 DOI:
General Description
4-(Trifluoromethyl)phenol molecule, bound at the active site of H61T (His-61→Thr) mutant, shows strong density.4-Trifluoromethylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
4-(TRIFLUOROMETHYL)PHENOXYACETIC ACID
4-Trifluoromethylsalicylic acid
2-Hydroxy-5-trifluoromethylbenzonitrile
2'-hydroxy-5'-(trifluoroMethyl)acetophenone
2-amino-alpha,alpha,alpha-trifluoro-p-creso
1of3
Global( 438)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | sales@fluoropharm.com | China | 1377 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
QINGDAO HONG JIN CHEMCIAL CO.,LTD. | 532-83657313 | hjt@hong-jin.com | China | 228 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shanghai Worldyang Chemical Co.,Ltd. | ,+86-21-56795779; +8613651600618 | sales@worldyachem.com | China | 879 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from 4-Trifluoromethylphenol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-11-02 | 4-Trifluoromethylphenol
402-45-9
|
US $0.00-0.00 / kg | 1kg | 99% | 50000kg | Hebei Kingfiner Technology Development Co.Ltd | ||
2023-02-21 | 4-(Trifluoromethyl)phenol
402-45-9
|
US $0.00 / KG | 1KG | 99.4% | 100 tons | Honest Joy Holdings Limited
|
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2020-07-06 | 4-Trifluoromethylphenol
402-45-9
|
US $100.00 / KG | 1KG | 99% | Customized | Career Henan Chemical Co |
- 4-Trifluoromethylphenol
402-45-9
- US $0.00-0.00 / kg
- 99%
- Hebei Kingfiner Technology Development Co.Ltd
- 4-(Trifluoromethyl)phenol
402-45-9
- US $0.00 / KG
- 99.4%
- Honest Joy Holdings Limited
- 4-Trifluoromethylphenol
402-45-9
- US $100.00 / KG
- 99%
- Career Henan Chemical Co
402-45-9(4-Trifluoromethylphenol)Related Search:
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4-(Trifluoromethyl)benzene-1-sulfonyl chloride
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1of4
alpha,alpha,alpha-Trifluoro-p-cresol,loosecrystals
Phenol, 4-(trifluoromethyl)-
P-HYDROXYBENZOTRIFLUORIDE
P-(TRIFLUOROMETHYL)PHENOL
ALPHA,ALPHA,ALPHA-TRIFLUORO-4-CRESOL
ALPHA,ALPHA,ALPHA-TRIFLUORO-P-CRESOL
4-HYDROXYBENZOTRIFLUORIDE
4-HYDROXY-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE
4-Hydroxy-α,α,α-trifluorotoluene
α,α,α-Trifluoro-p-cresol
4-Hydroxybenxotrifluoride
ALPHA,ALPHA,ALPHA-TRIFLUORO-P-CRESOL, 99 %
4-HydroxytrifluoromethylBenzene
4-Hydroxybenzotrifluoride,98%
4-Hydroxybenzotrifluoride99%
4-Hydroxybenzotrifluoride 99%
TRIFLUORO-PARA-CRESOL
4/p-Trifluoromethylaniline
α,α,α-Trifluoro-p-cresol, 4-Hydroxybenzotrifluoride
TFMPO
alpha,alpha,alpha-Trifluoro-p-cresol,98%
4-HYDROXYBENZOTRIFLUORI
4-(Trifluoromethyl)phenol ,98%
4-trifluorotoluolphenol
alpha,alpha,alpha-Trifluoro-p-cresol, 98% 1GR
alpha,alpha,alpha-Trifluoro-p-cresol, 98% 5GR
4-Hydroxy-alpha,alpha,alpha-trifluorotoluene
alpha,alpha,alpha-Trifluoro-p-cresol
4-(Trifluoromethyl)phenol
p-TrifluoroMethylphenyl
4-(TrifluoroMethyl)phenol 97%
4-(TrifluoroMethyl)phenol, 97+%
α,α,α-Trifluoro-p-cresol
4-Hydroxybenzotrifluoride
4-Hydroxy-α,α,α-trifluorotoluene
p-Hydroxybenzotrifluoride
p-Trifluoromethylphenol
4-Hydroxybenzotrifluoride for synthesis
Fluoxetine EP Impurity D
Fluoxetine Hydrochloride Impurity Ⅱ:4-Trifluoromethylphenol
P-Trifluoromethyl
Fluoxetine Impurity 4
Fluoxetine Impurity 4(EP-D)
4-Hydroxybenzotrifluoride>
4-Hydroxybenzotrifluoride (alpha-Trifluoro p-Cresol
Fluoxetine Hydrochloride Impurity Ⅱ:4-Trifluoromethylphenol
?,?,?-trifluoro-p-cresol
4-(TRIFLUOROMETHYL)PHENOL
Fluoxetine Impurity 4(Fluoxetine EP Impurity D)
402-45-9
402-56-9
C7H5F3O
Building Blocks
Oxygen Compounds
Phenols
Organic Building Blocks
Fluorochemicals
Trifluoromethylbenzene serise
Aromatic Phenols
Phenol&Thiophenol&Mercaptan
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