ChemicalBook >> CAS DataBase List >>S-Trityl-L-cysteine
S-Trityl-L-cysteine
- CAS No.
- 2799-07-7
- Chemical Name:
- S-Trityl-L-cysteine
- Synonyms
- H-CYS(TRT)-OH;Dimethyl 5-bromopyridine-2,3-dicarboxylate;H-L-Cys(Trt)-OH;S-Tritylcysteine;H-Cys(Trt)-OH (Cys of Animal Origin);NSC 83265;L-Cys(Trt)-OH;CYSTEINE(TRT)-OH;EG5 INHIBITOR II;TRITYL-L-CYSTEINE
- CBNumber:
- CB7164332
- Molecular Formula:
- C22H21NO2S
- Molecular Weight:
- 363.47
- MDL Number:
- MFCD00002611
- MOL File:
- 2799-07-7.mol
- MSDS File:
- SDS
Last updated:2024-06-30 15:45:59
| Melting point | 182-183 °C (dec.)(lit.) |
|---|---|
| Boiling point | 524.7±50.0 °C(Predicted) |
| Density | 1.1342 (rough estimate) |
| refractive index | 111 ° (C=0.8, 0.04mol Ethanolic HCl) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to 20 mg/ml). |
| form | White to off-white solid. |
| pka | 2.22±0.10(Predicted) |
| color | White or off-white |
| optical activity | [α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl |
| BRN | 2339626 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
| CAS DataBase Reference | 2799-07-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AY7710000 | |||||||||
| HS Code | 29309090 | |||||||||
| Toxicity | dog,LDLo,intravenous,150mg/kg (150mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),National Technical Information Service. Vol. PB81-109993, | |||||||||
| NFPA 704 |
|
S-Trityl-L-cysteine price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 164739 | (+)-S-Trityl-L-cysteine 97% | 2799-07-7 | 5g | $185 | 2025-03-01 | Buy |
| TCI Chemical | T2522 | S-Trityl-L-cysteine >95.0%(T) | 2799-07-7 | 5g | $49 | 2025-03-01 | Buy |
| Alfa Aesar | L14384 | (+)-S-Trityl-L-cysteine 97% | 2799-07-7 | 1g | $25.2 | 2024-06-20 | Buy |
| Alfa Aesar | L14384 | (+)-S-Trityl-L-cysteine 97% | 2799-07-7 | 5g | $57.6 | 2024-06-20 | Buy |
| Cayman Chemical | 23236 | S-trityl-L-Cysteine ≥98% | 2799-07-7 | 1g | $25 | 2025-03-01 | Buy |
S-Trityl-L-cysteine Chemical Properties,Uses,Production
Description
S-Trityl-cysteine (2799-07-7) is a cell permeable inhibitor of mitotic kinesin Eg5 (IC50 for inhibition of basal ATPase activity = 1 μM; IC50 for inhibition of microtubule-activated ATPase activity = 140 nM). Mean growth concentration (GI50) of 1.31 μM for a panel of 60 different tumor cell lines.Chemical Properties
almost white to light yellow granular powderUses
(+)-S-Trityl-L-cysteine, a non-natural, sulfur-containing amino acid is commonly used as a reagent in solution phase peptide synthesis (SPPS). It is also used as a metal-binding agent to synthesize substituted ferrocenoyl peptide conjugates using HBTU peptide coupling reagent for the cation-sensing applications solution via peptide-metal interactions.
Uses
A protected cysteine for peptide synthesis. S-Trityl-L-cysteine (STLC) is a tight-binding inhibitor of Eg5 that prevents mitotic progression. It has proven antitumor activity as shown in the NCI 60 tumor cell line screen.Definition
ChEBI: (2R)-2-amino-3-[(triphenylmethyl)thio]propanoic acid is a benzenoid aromatic compound.Biological Activity
Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC 50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC 50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC 50 of 700 nM. Displays antitumor activity.storage
Store at +4°CReferences
1) DeBonis et al. (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities; Mol. Cancer Ther. 3 1079 2) Brier et al. (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5; Biochemistry 43 13072 3) Skoufias et al. (2006) S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression; J. Biol. Chem., 281 17559S-Trityl-L-cysteine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 254)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from S-Trityl-L-cysteine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-07-02 | (+)-S-Trityl-L-cysteine 97%
2799-07-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-07-06 | S-Trityl-L-cysteine
2799-07-7
|
US $1.00 / KG | 1KG | 99% | 20kg | Career Henan Chemical Co |
-
- (+)-S-Trityl-L-cysteine 97%
2799-07-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- S-Trityl-L-cysteine
2799-07-7
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
2799-07-7(S-Trityl-L-cysteine)Related Search:
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(+)-S-TRITYL-L-CYSTEINE 97%
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S-Trityl-L-cysteine≥ 98% (HPLC)
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EG5 INHIBITOR II
NSC 83265
S-(TRIPHENYLMETHYL)-L-CYSTEINE
(+)-S-TRITYL-L-CYSTEINE
L-Cysteine, S-(triphenylmethyl)-
S-Trityl-L-cysteine USP/EP/BP
H-Cys(Trt)-OH (Cys of Non Animal Origin)
(2R)-2-ammonio-3-[(triphenylmethyl)thio]propanoate
(2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid
Dimethyl 5-bromopyridine-2,3-dicarboxylate
H-L-Cys(Trt)-OH
S-Tritylcysteine
H-CYS(TRT)-OH
H-Cys(Trt)-OH (Cys of Animal Origin)
S-Tritylcysteine,Kinesin,StritylLCysteine,Apoptosis,328542,inhibit,cell cycle arrest,Inhibitor,NSC 83265,antitumor activities,NSC-83265,ATPase activity,kinesin Eg5,NSC83265,S trityl L Cysteine
Tritylthioalanine (H-Cys(Trt)-OH)
2799-07-7
2799-7-7
279-07-7
2800-07-07
7/7/2799
2799/7/7
328542
C6H53CSCD2CHNH2COOH
C6H53CSCH2CHNH2CO2H
Specialty Synthesis
Peptide Synthesis
Cysteine/Cystine
CARBOXYLIC ACID
Amino Acid Derivatives
Cell Cycle Regulation
Amino Acid Derivatives
Amino Acids & Derivatives
Aromatics
Chiral Reagents
Enzyme substrates
Amino Acids 13C, 2H, 15N