ChemicalBook >> CAS DataBase List >>Quinolinic acid
Quinolinic acid
- CAS No.
- 89-00-9
- Chemical Name:
- Quinolinic acid
- Synonyms
- PYRIDINE-2,3-DICARBOXYLIC ACID;2,3-PYRIDINEDICARBOXYLIC ACID;QUIN;2,3-Pyridinedicarboxylic;Pyridine-2,3-dicarboxylate;2,3-PyridinedicarboxylicAcid99%;109/KG;NSC 18836;NSC 13127;NSC 403247
- CBNumber:
- CB7316162
- Molecular Formula:
- C7H5NO4
- Molecular Weight:
- 167.12
- MDL Number:
- MFCD00006295
- MOL File:
- 89-00-9.mol
Last updated:2024-09-22 17:54:45
Melting point | 188-190 °C (dec.) (lit.) |
---|---|
Boiling point | 295.67°C (rough estimate) |
Density | 1.5216 (rough estimate) |
refractive index | 1.6280 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | 10g/l |
form | Crystalline Powder |
pka | 2.43(at 25℃) |
color | White to light yellow-beige |
Odor | odorless |
Water Solubility | 0.55 g/100 mL |
Merck | 14,8073 |
BRN | 137110 |
InChIKey | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
CAS DataBase Reference | 89-00-9(CAS DataBase Reference) |
EWG's Food Scores | |
FDA UNII | |
EPA Substance Registry System |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P304+P340+P312-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38-33 | |||||||||
Safety Statements | 26-36/37-24/25-37 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | US7967250 | |||||||||
TSCA | T | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29333999 | |||||||||
Toxicity | Focal injection of quinolinic acid into specific areas of the brain produces neuronal damage although sparing axons of passage. Similarities between the biochemical and morphological profiles of these lesions and human neuropathy seen in neurodegenerative diseases have led to the proposal that endogenous excitotoxins may play a role in such neurodegenerative disease states. Quinolinic acid is an intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals including man. The neuroexcitatory action is thought to be mediated via interaction with the N-methyl-D-aspartate (NMDA) receptor of the glutamate family. No mechanism for quinolinic acid removal, nor for synaptic inactivation, has been found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur. | |||||||||
NFPA 704 |
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Quinolinic acid price More Price(49)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P63204 | 2,3-Pyridinedicarboxylic acid 99% | 89-00-9 | 25g | $31.4 | 2025-03-01 | Buy |
Sigma-Aldrich | P63204 | 2,3-Pyridinedicarboxylic acid 99% | 89-00-9 | 100g | $34.8 | 2025-03-01 | Buy |
TCI Chemical | P0550 | 2,3-Pyridinedicarboxylic Acid >98.0%(GC)(T) | 89-00-9 | 25g | $25 | 2025-03-01 | Buy |
TCI Chemical | P0550 | 2,3-Pyridinedicarboxylic Acid >98.0%(GC)(T) | 89-00-9 | 500g | $199 | 2025-03-01 | Buy |
Alfa Aesar | A11414 | Pyridine-2,3-dicarboxylic acid, 99% | 89-00-9 | 25g | $23.65 | 2025-03-01 | Buy |
Quinolinic acid Chemical Properties,Uses,Production
Chemical Properties
White powder;Light yellow powderUses
Quinolinic acid is an endogenous NMDA agonist. Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid is an ?excitotoxic? metabolite and an agonist of N-methyl-D-aspartate receptors. properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders. Quinolinic acid is a potent endogenous excitant at amino acid receptors in CNS.Uses
A matabolite of tryptophan and a putative NMDA receptor agonist.Uses
An inhibitor of glucose synthesis.Uses
Inhibits glucose synthesisDefinition
ChEBI: Quinolinic acid is a pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan. It has a role as a NMDA receptor agonist, a human metabolite, a mouse metabolite and an Escherichia coli metabolite. It is a conjugate acid of a quinolinate(1-) and a quinolinate.Synthesis Reference(s)
Journal of the American Chemical Society, 71, p. 3020, 1949 DOI:
Hazard
A poison by skin contact. Moderately toxic by ingestion. A mild skin irritant.Industrial uses
The use of quinolinic acid during flotation of hematite results in the adsorption of quinoline on hematite, allowing amine to selectively adsorb onto the hematite surface.Biological Activity
Endogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.Safety Profile
A poison by skin contact. Moderately toxic by ingestion. Experimental reproductive effects. A mdd skinn irritant. When heated to decomposition it emits toxic vapors of NOx.storage
Room temperatureQuinolinic acid Preparation Products And Raw materials
Raw materials
Potassium permanganate
KZESTKDHUUMSOC-UHFFFAOYSA-N
2,3-Pyridinedicarboxylic acid copper(II) salt
Diethyl pyridine-2,3-dicarboxylate
5-BROMO-8-NITROQUINOLINE
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Preparation Products
3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID
METHYL 3-CYANOPYRIDINE-2-CARBOXYLATE
3-Amino-2-pyridinecarboxylic acid
5-Methylpyridine-2,3-dicarboxylic acid
3-CARBAMOYLPICOLINIC ACID
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Global( 564)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12454 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5965 | 58 |
shandong exelon biochem co.ld | +86-533-2119995 +8615053330977 | 451614802@QQ.com | China | 28 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21696 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 7836 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from Quinolinic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2025-04-11 | Quinolinic acid
89-00-9
|
US $0.00 / kg | 1kg | 99% | 300mt | Jinan Finer Chemical Co., Ltd | ||
2024-09-23 | 2,3-Pyridinedicarboxylic acid
89-00-9
|
US $0.00 / kgs | 1000kgs | 99% | 10 tons | shandong exelon biochem co.ld | ||
2024-08-05 | Quinolinic Acid
89-00-9
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD |
- Quinolinic acid
89-00-9
- US $0.00 / kg
- 99%
- Jinan Finer Chemical Co., Ltd
- 2,3-Pyridinedicarboxylic acid
89-00-9
- US $0.00 / kgs
- 99%
- shandong exelon biochem co.ld
- Quinolinic Acid
89-00-9
- US $5.00-2.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
89-00-9(Quinolinic acid)Related Search:
QuinolinicAcid>99%
Pyridin-2,3-dicarbonsaeure
2,3-PYRIDINEDICARBOXYLIC ACID (QUINOLINIC ACID)
2,3-pyridine dicarbo
AKOS BBS-00003814
AKOS AUF2085
Quinolinic Acid 99%
2,3-Pyridinedicarboxylic acid, 99% 100GR
2,3-Pyridinedicarboxylic acid, 99% 25GR
NSC 13127
NSC 18836
NSC 403247
2,3-PYRIDINEDICARBOXYLIC ACID FOR SYNTHE
Pyridinecarboxylic acid-2,3- two
2,3-Pyridinedicarboxylic acid 99%
2,3-PYRIDINEDICARBOXYLIC ACID
AKOS AUF2085
2,3-pyridinediacrboxylic acid
Pyridine-2,3-dicarboxylic acid (quinolinic acid)
109/KG
2,3-Pyridinedicarboxylic acid Vetec(TM) reagent grade, 98%
RARECHEM AL BO 0810
QUINOLIC ACID
QUINOLINIC ACID
2,3 PYRIDINE DICARBOXYLIC ACID (AS PER INVOICE AND PACKING LIST)
PYRIDINE-2,3-DICARBOXYLI ACID
2,3-PyridinedicarboxylicAcid>
Pyridine-2,3-Dicarboxylic Acid,99%,
2,3-PyridinedicarboxyL
2,3-PyridinedicarboxylicAcid99%
2,3-Pyridinedicarboxylic
2,3-PYRIDINEDICARBOXYLIC ACID
PYRIDINE-2,3-DICARBOXYLIC ACID
Pyridine-2,3-dicarboxylate
QUIN
Quinolinic acid (2,3-pyridinedihydroxy acid)
Pyridine Dicarbonylic Acid
89-00-9
98-00-9
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C7 and C8
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