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ChemicalBook >> CAS DataBase List >>Coenzyme A

Coenzyme A

CAS No.
85-61-0
Chemical Name:
Coenzyme A
Synonyms
COA;COA-SH;COENZYME A HYDRATE;Lucina;Coalip;Aluzime;Thiol-CoA;SHUIRUJIE;COENZYME A;CONENZYME A
CBNumber:
CB8854470
Molecular Formula:
C21H36N7O16P3S
Molecular Weight:
767.53
MDL Number:
MFCD06795839
MOL File:
85-61-0.mol
MSDS File:
SDS
Last updated:2025-04-06 17:48:18

Coenzyme A Properties

Density 1.96±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility PBS (pH 7.2): 10 mg/ml
form A crystalline solid
pka 9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+)
Merck 13,2491
BRN 77809
LogP -4.358 (est)
EWG's Food Scores
FDA UNII
EPA Substance Registry System

SAFETY

Risk and Safety Statements

Symbol(GHS)  sòng bạc tiền thậtLiên kết đăng nhập
GHS07
Signal word  Warning
Hazard statements  H319-H315-H335
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Safety Statements  24/25
WGK Germany  3
F  1-10
TSCA  Yes
HS Code  2933299090
NFPA 704
0
1 0

Coenzyme A price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C4282 Coenzyme A hydrate ≥85% (UV, HPLC) 85-61-0 10mg $81.3 2025-03-01 Buy
Sigma-Aldrich C4282 Coenzyme A hydrate ≥85% (UV, HPLC) 85-61-0 25mg $135 2025-03-01 Buy
Alfa Aesar J13787 Coenzyme A trihydrate, free acid, Affymetrix/USB 85-61-0 50mg $108.19 2022-12-16 Buy
Alfa Aesar J13787 Coenzyme A trihydrate, free acid, Affymetrix/USB 85-61-0 1g $1350.25 2022-12-16 Buy
Cayman Chemical 16147 Coenzyme A ≥98% 85-61-0 10mg $74 2025-03-01 Buy
Product number Packaging Price Buy
C4282 10mg $81.3 Buy
C4282 25mg $135 Buy
J13787 50mg $108.19 Buy
J13787 1g $1350.25 Buy
16147 10mg $74 Buy

Coenzyme A Chemical Properties,Uses,Production

Description

Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid in a 5-step process that requires ATP. The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.

Chemical Properties

yellowish lyophilisate

Uses

Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements.

Uses

A hydrated form of Coenzyme A (CoA) is a useful biochemical research chemical, used in the preparation of high-yielding cell-free protein synthesis platforms.

Definition

ChEBI: Tetraanion of coenzyme A.

General Description

Coenzyme A is structurally composed of 2-aminoethanethiol, pantothenic acid and phosphorylated adenosine phosphate.

Biochem/physiol Actions

Coenzyme A is a cofactor involved in acyl group transfer. It is essential for carbohydrate, lipid and protein metabolism. Coenzyme A acts as a cofactor for vitamin B coenzymes.

Purification Methods

The white powder is best stored in an inert atmosphere in the dark in sealed ampoules after drying in vacuo over P2O5 at 34o. It has UV: max 259 nm ( 16,800) in H2O. [Buyske et al. J Am Chem Soc 76 3575 1954.] It is soluble in H2O but insoluble in EtOH, Et2O and M2CO. It is readily oxidised in air and is best kept as the more stable trilithium salt [Moffat & Khorana J Am Chem Soc 83 663 1961; see also Beinert et al. J Biol Chem 200 384 1953, De Vries et al. J Am Chem Soc 72 4838 1950, Gregory et al. J Am Chem Soc 74 854 1952 and Baddiley Adv Enzymol 16 1 1955]. [Beilstein 26 III/IV 3663.]
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View Lastest Price from Coenzyme A manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
sòng bạc tiền thậtLiên kết đăng nhập 2025-04-06 Coenzyme A
85-61-0
 US $0.00 / kg 1kg 99.8% 1000 kg BINBO BIOLOGICAL CO.,LTD
sòng bạc tiền thậtLiên kết đăng nhập 2025-01-08 Acetyl Coenzyme
85-61-0
 US $50.00-30.00 / KG 1KG 99.50% 20tons Wuhan Boyuan Import & Export Co., LTD
sòng bạc tiền thậtLiên kết đăng nhập 2025-01-08 Coenzyme
85-61-0
 US $20.00-12.00 / KG 1KG 99.50% 20tons Wuhan Boyuan Import & Export Co., LTD
  • sòng bạc tiền thậtLiên kết đăng nhập
  • Coenzyme A
    85-61-0
  • US $0.00 / kg
  • 99.8%
  • BINBO BIOLOGICAL CO.,LTD
  • sòng bạc tiền thậtLiên kết đăng nhập
  • Acetyl Coenzyme
    85-61-0
  • US $50.00-30.00 / KG
  • 99.50%
  • Wuhan Boyuan Import & Export Co., LTD
  • sòng bạc tiền thậtLiên kết đăng nhập
  • Coenzyme
    85-61-0
  • US $20.00-12.00 / KG
  • 99.50%
  • Wuhan Boyuan Import & Export Co., LTD

Coenzyme A Spectrum

Lucina Thiol-CoA Coenzyme A,75%,free acid, lyophilized Coenzyme A, free acid, hydrate (COA) coenzyme A(4-) COENZYME A [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid CONENZYME A Coenzyme a, free acid Coenzyme A, free acid, lyophilized, min. 75% (enzym.) COENZYME A FREE ACID FROM YEAST Coenzyme A, free acid, lyophilized, 75% Coenzyme A / Q0 / Q10 COENZYM A FREE ACID COENZYME A (COA) CoenzyMe A hydrate (free acid) Coenzyme A hydrate,CoA [5-(6-Aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid Adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) P'-[(R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester Aluzime Coenzyme ASH D-Coenzyme A Coalip SHUIRUJIE Coenzyme A, Free Acid(CoA) COENZYMEA 96%, TRILITH. D1GM Coenzyme A USP/EP/BP (((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(((hydroxy((hydroxy((R)-3-hydroxy-2,2-dimethyl-3-((2-((2-sulfanylethyl)carbamoyl)ethyl)carbamoyl)propoxy)phosphoryl)oxy)phosphoryl)oxy)methyl)oxolan-3-yl)oxy)phosphonic acid Delivery Coenzyme CoASH (Coenzyme A-SH), 80% [[(2S,3R,4S,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate COENZYME A HYDRATE COA COA-SH Coenzyme A (8CI, 9CI, ACI) Acetyl Coenzyme 85-61-0 85-16-0 C21H36N7O16P3S C21H36N7O16P3S3H2O C21H38N7O17P3S C21H32N7O16P3S C21H36N7O16P3SxH2O C21H36N7O16P3SH2O Metabolic Libraries Lipid Library Nucleosides, Nucleotides, Oligonucleotides Biochemicals and Reagents BioChemical Coenzyme A and Derivatives Metabolomics Vitamin series 85-61-0
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