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ChemicalBook >> CAS DataBase List >> 4-Aminopyridine

4-Aminopyridine

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  • $10 - $4129.82
  • Product name: 4-Aminopyridine
  • CAS: 504-24-5
  • MF: C5H6N2
  • MW: 94.11
  • EINECS:207-987-9
  • MDL Number:MFCD00006439
  • Synonyms:4-AMINOPYRIDINE,REAGENT;AMINOPYRIDINE, 4-(P);PARA-AMINOPYRIDINE;4-AMINO PYRIDINE PYRIDIN-4-YLAMINE;Phillips 1861;phillips1861 ;Pimadin (free base);Prc 1237
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  • Absolute Chiral
  • AHH
  • AK Scientific
  • Alfa Aesar
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  • Aronis compounds
  • Atlantic Research Chemicals
  • Azepine
  • Biosynth Carbosynth
  • BroadPharm
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  • 10gm:
  • 1000g
  • 10mM(in 1mL H2O)
  • ManufacturerAbsolute Chiral
  • Product numberD1326-00-N
  • Product description4-Aminopyridine 95%
  • Packaging5G
  • Price$28
  • Updated2022-12-16
  • Buy
  • ManufacturerAHH
  • Product numberMT-41399
  • Product description4-Aminopyridine 97%
  • Packaging1000g
  • Price$610
  • Updated2022-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ94087
  • Product description4-Aminopyridine
  • Packaging5g
  • Price$12
  • Updated2022-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ61470
  • Product description4-Aminopyridine, 99+%
  • Packaging25g
  • Price$55.65
  • Updated2025-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberA12405
  • Product description4-Aminopyridine, 98%
  • Packaging50g
  • Price$69.8
  • Updated2025-03-01
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  • ManufacturerAlfa Aesar
  • Product numberJ61470
  • Product description4-Aminopyridine, 99+%
  • Packaging100g
  • Price$153.65
  • Updated2025-03-01
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  • ManufacturerAlfa Aesar
  • Product numberA12405
  • Product description4-Aminopyridine, 98%
  • Packaging250g
  • Price$230.65
  • Updated2025-03-01
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  • ManufacturerAlfa Aesar
  • Product numberA12405
  • Product description4-Aminopyridine, 98%
  • Packaging1000g
  • Price$812.65
  • Updated2025-03-01
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM1555287
  • Product description4-AMINOPYRIDINE 99.00%
  • Packaging5MG
  • Price$502
  • Updated2022-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM1555287
  • Product description4-AMINOPYRIDINE 99.00%
  • Packaging100G
  • Price$2353.66
  • Updated2022-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM1555287
  • Product description4-AMINOPYRIDINE 99.00%
  • Packaging250G
  • Price$4129.82
  • Updated2022-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3530
  • Product description4-Aminopyridine
  • Packaging10mM(in 1mL H2O)
  • Price$50
  • Updated2022-12-16
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  • ManufacturerApexBio Technology
  • Product numberB3530
  • Product description4-Aminopyridine
  • Packaging50g
  • Price$63
  • Updated2022-12-16
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  • ManufacturerAronis compounds
  • Product numberc08484
  • Product description4-pyridinamine
  • Packaging100mg
  • Price$80
  • Updated2022-12-16
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  • ManufacturerAtlantic Research Chemicals
  • Product numberAE00203
  • Product description4-Aminopyridine 95%
  • Packaging10gm:
  • Price$21.21
  • Updated2022-12-16
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  • ManufacturerAzepine
  • Product numberAZ0001-0464
  • Product description4-Aminopyridine 98
  • Packaging25g
  • Price$15
  • Updated2022-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Absolute Chiral D1326-00-N 4-Aminopyridine 95% 5G $28 2022-12-16 Buy
AHH MT-41399 4-Aminopyridine 97% 1000g $610 2022-12-16 Buy
AK Scientific J94087 4-Aminopyridine 5g $12 2022-12-16 Buy
Alfa Aesar J61470 4-Aminopyridine, 99+% 25g $55.65 2025-03-01 Buy
Alfa Aesar A12405 4-Aminopyridine, 98% 50g $69.8 2025-03-01 Buy
Alfa Aesar J61470 4-Aminopyridine, 99+% 100g $153.65 2025-03-01 Buy
Alfa Aesar A12405 4-Aminopyridine, 98% 250g $230.65 2025-03-01 Buy
Alfa Aesar A12405 4-Aminopyridine, 98% 1000g $812.65 2025-03-01 Buy
American Custom Chemicals Corporation CHM1555287 4-AMINOPYRIDINE 99.00% 5MG $502 2022-12-16 Buy
American Custom Chemicals Corporation CHM1555287 4-AMINOPYRIDINE 99.00% 100G $2353.66 2022-12-16 Buy
American Custom Chemicals Corporation CHM1555287 4-AMINOPYRIDINE 99.00% 250G $4129.82 2022-12-16 Buy
ApexBio Technology B3530 4-Aminopyridine 10mM(in 1mL H2O) $50 2022-12-16 Buy
ApexBio Technology B3530 4-Aminopyridine 50g $63 2022-12-16 Buy
Aronis compounds c08484 4-pyridinamine 100mg $80 2022-12-16 Buy
Atlantic Research Chemicals AE00203 4-Aminopyridine 95% 10gm: $21.21 2022-12-16 Buy
Azepine AZ0001-0464 4-Aminopyridine 98 25g $15 2022-12-16 Buy

Properties

Melting point :155-158 °C (lit.)
Boiling point :273 °C (lit.)
Density :1.26
vapor pressure :0.046Pa at 25℃
refractive index :1.5560 (estimate)
Flash point :156°C
storage temp. :2-8°C
solubility :H2O: soluble50mg/mL, clear, colorless
form :Crystalline Powder, Solid or Crystals
pka :9.114(at 25℃)
color :White to faint grey to light yellow
Water Solubility :Soluble in water(112 g/L at 20 deg C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.
Merck :14,3933
BRN :105782
Stability :Hygroscopic
InChIKey :NUKYPUAOHBNCPY-UHFFFAOYSA-N
LogP :-0.76 at pH7.4
CAS DataBase Reference :504-24-5(CAS DataBase Reference)
NIST Chemistry Reference :
EPA Substance Registry System :

Safety Information

Symbol(GHS): sòng bạc tiền thậtLiên kết đăng nhậpsòng bạc tiền thậtLiên kết đăng nhậpsòng bạc tiền thậtLiên kết đăng nhập
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger sòng bạc tiền thậtLiên kết đăng nhập P264, P270, P301+P310, P321, P330,P405, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger sòng bạc tiền thậtLiên kết đăng nhập P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

4-Aminopyridine (4-AP) is a non-selective blocker of voltage-dependent K+-channels (Kv proteins in the KCN gene family). It has greatest potency at Kv1 (KCNA) and Kv3 (KCNC) family members (IC50s = 290, 590, 195, 13, 29, and 100 μM for subunits 1.1, 1.2, 1.3, 1.4, 3.1, and 3.2, respectively). 4-AP also blocks Kv2 and Kv4 subunits at millimolar concentrations. When administered orally, 4-AP has benefits against multiple sclerosis, while injection into the brain produces epileptiform activity and can be used to study seizures.

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