alkyl bromide;Building Blocks;C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Aromatics Compounds;Bromopyridines;Halopyridines;Pyridine series;Aromatics;Bases & Related Reagents;Nucleotides;Brominated heterocyclic series;Nitrogen cyclic compounds;blocks;Bromides;Pyridines;pyridine derivative;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridine;Pyridines derivates;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;bc0001;624-28-2
Mol File:
624-28-2.mol
2,5-Dibromopyridine Chemical Properties
Melting point
92-95 °C (lit.)
Boiling point
235 °C / 772mmHg
density
2.0383 (rough estimate)
refractive index
1.5800 (estimate)
Fp
62℃
storage temp.
Inert atmosphere,Room Temperature
solubility
Chloroform (Slightly), Methanol (Slightly)
pka
-1.57±0.10(Predicted)
form
Crystalline Powder
color
Almost white or light beige to brown
Water Solubility
insoluble
BRN
109099
InChI
InChI=1S/C5H3Br2N/c6-4-1-2-5(7)8-3-4/h1-3H
InChIKey
ZHXUWDPHUQHFOV-UHFFFAOYSA-N
SMILES
C1(Br)=NC=C(Br)C=C1
CAS DataBase Reference
624-28-2(CAS DataBase Reference)
2,5-Dibromopyridine Usage And Synthesis
Chemical Properties
2,5-Dibromopyridine is an off-white crystalline solid. It is insoluble in water but soluble in strong polar organic solvents. It exhibits strong alkalinity.
Uses
2,5-Dibromopyridine (cas# 624-28-2) is a compound useful in organic synthesis.
Preparation
To synthesize 2,5-dibromopyridine, follow these steps: Add 2-amino-5-bromopyridine (13.0 kg) into a water-cooled solution at 10 °C. Slowly add 47% aqueous hydrogen bromide (37 L) to the mixture. Introduce liquid bromine (11 L) into the mixture. Maintain the reaction temperature below 10 °C. Prepare a solution of NaNO2 (16.1 kg) and H2O (19 L) and add it dropwise to the mixture while keeping the temperature between 0-5 °C. Stir the reaction mixture for 30 minutes. Treat the mixture with a solution of NaOH (28.0 kg) in water (30 L) at a controlled rate below 20-25 °C. Extract the reaction mixture with diethyl ether (3 × 40 L). Dry the organic layer with anhydrous Na2SO4. Remove the desiccant by filtration. Evaporate the resulting filtrate under reduced pressure to dryness. Suspend the residue in heptane (10 L). Collect the target product molecule, 2,5-dibromopyridine, by filtration. Synthesis method of 2,5-dibromopyridine
Packing &shipping&Payment
Packing:25kg/drum Shipping:by sea or by air Payment:T/T,western union,moneygram Packaging Details drum Port:Tianjin Lead Time :
Quantity(Kilograms)
1 - 10000
>10000
Est. Time(days)
5
To be negotiated
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