Retinoic acid synthesis
- Product Name:Retinoic acid
- CAS Number:302-79-4
- Molecular formula:C20H28O2
- Molecular Weight:300.44
68-26-8
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$28.00/50mg
302-79-4
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$5.00/100mg
1.2
2) Take 1L of bis- (3-methyl-1-imidazole) ethylene tetrafluoroborate and add RuCl2 (PPh3) 3 (the added amount is 1mol% of tretinoin), stir to dissolve,Then add 2mol of retinoid acid in the dark,The reaction was carried out in an oxygen atmosphere of 1 atm at 50 ° C for 3 hours. After the reaction, n-hexane was added for extraction,The extract was collected and dried to obtain crude tretinoin.The crude retinoic acid product obtained above was suspended in absolute ethanol, heated to 80 ° C under reflux to dissolve, and then slowly cooled to 10 ° C with stirring, allowed to stand, filtered, washed with a small amount of ethanol, and dried in vacuo to obtain pure retinoic acid product. The total yield is 90.2% and the purity is 99%.The structure identification of the prepared tretinoin was carried out, and the obtained compound was indeed the target compound.
3899-20-5
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302-79-4
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$5.00/100mg
116-31-4
237 suppliers
$18.00/250mg
302-79-4
729 suppliers
$5.00/100mg
116-31-4
237 suppliers
$18.00/250mg
67890-45-3
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302-79-4
729 suppliers
$5.00/100mg
67890-46-4
0 suppliers
inquiry