p-Hydroxybenzaldehyde-Application
Dec 19,2019
4-Hydroxybenzaldehyde is colorless crystalline powder. Melting point: 115-116 ℃, the relative density is 1.129 (30/4℃). In the air, 4-Hydroxybenzaldehyde is easily to be sublimated. 4-Hydroxybenzaldehyde is easily soluble in alcohol, ether, acetone, and ethyl acetate, slightly soluble in water (at 30.5℃, its water solubility is 1.38g/100ml); it can also be dissolved in benzene (at 65℃, its solubility in benzene is 3.68g/ml). It has aromatic odor.
4-Hydroxybenzaldehyde is one of the three isomers of hydroxybenzaldehyde. It can be found in the orchids Gastrodia elata and Galeola faberi. It is also found in vanilla[1-2].
4-hydroxybenzaldehyde is a hydroxybenzaldehyde that is benzaldehyde substituted with a hydroxy group at position C-4. It has a role as a plant metabolite, a mouse metabolite and an EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor.
4-Hydroxybenzaldehyde reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons. The reaction is catalyzed by 4-hydroxybenzaldehyde dehydrogenase. 4-Hydroxybenzaldehyde is found in the benzoate degradation via hydroxylation, bisphenol A degradation, toluene and xylene degradation, and biosynthesis of phenylpropanoids pathways.
Fig 1. Chemical structure formula of p-Hydroxybenzaldehyde
References
[1] Ha, J. H.; Lee, D. U.; Lee, J. T.; Kim, J. S.; Yong, C. S.; Kim, J. A.; Ha, J. S.; Huh, K. (2000). "4-Hydroxybenzaldehyde from Gastrodia elata B1. Is active in the antioxidation and GABAergic neuromodulation of the rat brain". Journal of Ethnopharmacology. 73 (1–2): 329–333.
[2] Li, Y. M.; Zhou, Z. L.; Hong, Y. F. (1993). "(title in Chinese)" [Studies on the phenolic derivatives from Galeola faberi Rolfe]. Yao xue xue bao = Acta pharmaceutica Sinica (in Chinese). 28 (10): 766–771.
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- 4-Hydroxybenzaldehyde: Synthesis, applications and bioactivities Jun 8, 20234-Hydroxybenzaldehyde is one of the three isomers of hydroxybenzaldehyde. It can be found in the orchids Gastrodia elata and Galeola faberi. It is also found in vanilla.
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4-Hydroxybenzaldehyde
123-08-0
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